Premphase® (conjugated estrogens/ medroxyprogesterone acetate tablets) is a convenient single-tablet, cyclic hormone replacement therapy (HRT). Premphase consists of a complex blend of natural estrogens plus progestin and is indicated for the treatment of moderate to severe vasomotor symptoms associated with menopause, the treatment of vulvar and vaginal atrophy, and the prevention of osteoporosis. When estrogen is given alone, it may cause an overgrowth of the uterine lining, which may lead to a form of cancer. This risk is greatly reduced when progestin is taken in combination with estrogen, as with Premphase. This risk does not affect women who no longer have a uterus. Therefore, HRT is not intended for women who have had a hysterectomy.
Dosage and Administration
Follow a 28-day cycle. Take 1 maroon Premarin tablet every day for the first 14 days; on the 15th day, begin taking 1 light-blue tablet daily.
Studies show that 30% of women sometimes neglect to take the progestin part in a two-tablet estrogen/progestin regimen. One-tablet Premphase makes it easy for women to know when they have taken their medication.
With Premphase, many women still experience predictable, monthly bleeding, similar to a period. This does not signal the return of fertility.
Side Effects
Estrogen can increase the risk of cancer of the uterus. Progestin combined with estrogen, as in Premphase, reduces this risk. Women who have had a hysterectomy do not have this risk. Premphase contains progestin, which may have unfavorable effects on blood sugars and may worsen a diabetic condition. Side effects of Premphase include
- blood clots
- nausea
- abdominal pain
- breast tenderness
- irregular bleeding
- headache
- hair loss
Premphase is not for every woman
You should not take Premphase if you have had any breast or uterine cancer, abnormal vaginal bleeding, abnormal blood clotting, or if you think or know you are pregnant. Pregnant women should not take Premphase because of possible risk to the fetus. You should also not take Premphase if you have liver disease or have had a stroke. If you have heart disease, you and your health care provider may decide you should not take Premphase. Tell your health care provider about your personal and family medical history.
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